Vanderbilt is now 23-8 overall, 12-4 in the Southeastern Conference.
The Commodores lead the all-time series with the Tigers 21-14, 6-3 in the SEC Tournament.
Senior forward Christina Wirth's 18 points led Vandy in scoring for the 15th time this season.
Sophomore guard Jence Rhoads was also in double figures with 15 points, one off of her career high.
Wirth and junior guard Merideth Marsh each played all 40 minutes of today's game for the Commodores, the second consecutive game they have each gone the distance.
Vanderbilt is now 39-24 all-time in the SEC Tournament, good for a .612 winning percentage, second best all time in the event. The 39 wins are tied with Georgia for second-most all time behind Tennessee.
The Commodores won the battles for points in the paint (28-22), points off turnovers (18-6) and second chance points (11-6).