The loss for Arkansas (19-9, 2-9) was its fifth straight since beating Mississippi State on Jan. 27.
Vanderbilt jumped out to an early advantage in the first half after getting three 3-pointers from Merideth Marsh and Mooney, building a 16-10 lead.
But Arkansas responded in the last 6 minutes of the first half by hitting jump shots on nearly all its offensive possessions to cut Vanderbilt's lead to one at the break, 26-25.
Arkansas shot only 9-for-26 (35 percent) from the floor in the second half and got outrebounded 22-9 as the Commodores moved out to their 13-point win.
Whitney Jones scored 13 points and Sarah Pfeifer had 11 to lead Arkansas.
Sherwood reaches 1,000 point plateau:
With a layup at the 4:27 mark of the first half, senior Liz Sherwood became the 29th member of Vanderbilt's 1,000-point club off an assist from freshman Jence Rhoads. Sherwood finished the game with 10 points, moving into 27th place all-time at 1,006 career points, just ahead of current graduate assistant coach Caroline Williams.