Vanderbilt shot 50 percent from the field while holding the Gamecocks to just over 30 percent. The Commodores also continued their outstanding three-point defense, holding USC to 4 three-polnters on 14 attempts.
The Commodores opened a 37-14 lead at halftime after a 13-0 run midway through the opening period. The Gamecocks would get no closer than 21 in the second half.
Vanderbilt travels to Tuscaloosa on Sunday to face Alabama for a 2 p.m. CT tip-off.