Team Notes Vanderbilt trailed at the half for the first time this season.
The Commodores fell to 0-1 on the road after three straight home games to open the year.
For the first time this season Vanderbilt lost when scoring first and is now 2-1.
Individual Notes Walker May earned his first start of the year, starting at defensive end.
Casey Hayward's 11th career interception and third of the season ended South Carolina's opening drive. Hayward is now tied for sixth in Vanderbilt history with Reshard Langford, Manuel Young and Christie Hauck.
Richard Kent extended his streak to 16 games with a punt downed inside the 20-yard line when his second punt of the night was downed at the four-yard line.
Hayward's second pick of the first quarter moved him into a tie with Corey Chavous for fifth all-time at VU with 12 interceptions.
Hayward's two-interception performance makes him the second Commodore this season to have two picks in a game, joining Trey Wilson.
Carey Spear's 33-yard field kept him perfect on the year and put the Dores on the scoreboard first for the third time in four games this season. The 33-yard boot also tied his career-long.
Andre Hal collected his first interception of his career with a second quarter pick.
Jonathan Krause set a career-high with nine receptions.
Chris Marve's nine tackles moved him to 328 for his career. He needs 24 more to join the all-time top 10 at Vanderbilt.
Archibald Barnes recorded a career-best seven tackles after entering the game with five total for the season.
With 12 completions Larry Smith moved into eighth place (292) in career completions and seventh (295) in career attempts before leaving with an injury at the end of the third quarter.
Chase Garnham set a career-best with at team-high 10 tackles.
Chris Marve recorded his first career interception in the fourth quarter, picking off a pass in the end zone.
Kenny Ladler set a season-high with seven tackles.
Javon Marshall set a career-best with five tackles.
Jordan Rodgers completed a career-best four passes on a career-high seven attempts in relief duty.
Defense Chris Hayward's first quarter interception was the Commodores' 11th interception of the year and 13th forced turnover. Vanderbilt has forced a turnover in all four games.
With 7:20 left in the first quarter the defense held the Gamecocks on 4th and 1 with Chase Garnham getting credit for the tackle.
The Commodores continued to be stiff on defense in the first quarter, holding South Carolina scoreless in the opening quarter. The Dores have allowed three points in the first quarter all year.
Vanderbilt recorded multiple interceptions for the fourth game in a row.
The Dores picked off four South Carolina passes after having five against Ole Miss and have nine in the last two games and 14 for the season.
Offense Vanderbilt improved to 4-for-6 on the year with a conversion on 4th down with a second quarter conversion.
The Commodores were held to season-lows in total yards (77), first downs (5) and points (3) struggling on third down going 1-for-14.
Special Teams Richard Kent averaged 41.3 yards per punt with three punts over 50 yards and two inside the 20-yard line.